The easiest method if the standardization require standardized solution of silver nitrate. J.E. Molecular Weight: 97.18. 2.9.2. In Volhard s method, it is used to determine the … All Rights Reserved. It can be painted onto a surface or kept as a colorless solution. Potassium thiocyanate - … Diethyl phosphorochloridate (10 g, 58 mmol) and anhydrous potassium thiocyanate (7.5 g, 77 mmol) were stirred at room temperature for 3 h, whereupon most of the potassium thiocyanate disappeared and a red solution was obtained. Organic compounds containing the functional group SCN are also called thiocyanates. Shaban, in Advances in Heterocyclic Chemistry, 1997. d-Glucose (119) reacted with potassium thiocyanate to give a product that was erroneously called the glucopyrano[3,2-d]oxazole (120) (36CB748; 45JOC267) or the glucopyrano[2,3-d]oxazole (121) [38CB590; 52CI(L)1034] structures. (13) has been used. δP −19.0 ppm. Potassium thiocyanate solution. The density of Thiocyanate is 1.89 grams per cubic centimeter. Potassium Thiocyanate Solution, 0.1 M, 500 mL. Neither Achieve nor the lead states and partners that developed the Next Generation Science Standards were involved in the production of this product, and do not endorse it. Thus this chemical is often used to create the effect of 'stigmata'. OSHA Vacated PELs: Potassium thiocyanate: No OSHA Vacated PELs are listed for this chemical. A mixture of arylalkene (1;1 mmol), potassium thiocyanate (2; KSCN; 2 mmol) and anhydrous FeCl3 (2 mmol) in acetonitrile (10 mL) was stirred at room temperature until completion of the reaction (2–12 h; monitored by TLC). This item can only be shipped to schools, museums and science centers. Our channel. Quantitative oxidation with sodium periodate (54JCS2645), acid strength measurements 1H NMR (68BCJ261), and 13C NMR (91MI6) spectrometry, however, indicated that the product is actually the furo[2,3-d]oxazolidin-5-yl acyclo C-nucleoside 123 (Z = S). Picture of reaction: Сoding to search: FeCl3 + 6 KSCN = K3FeSCN6 + 3 KCl. Potassium thiocyanate, 0.1N standardized solution is used in analytical chemistry for the quantitative determination of Fe(III). Search term: "Potassium thiocyanate solution" Compare Products: Select up to 4 products. Copyright © 2021 Elsevier B.V. or its licensors or contributors. Potassium Thiocyanate, 0.1 N Solution ACC# 88045 Section 1 - Chemical Product and Company Identification MSDS Name: Potassium Thiocyanate, 0.1 N Solution Catalog Numbers: M-077, M077, MCC-030332 Synonyms: Potassium isothiocyanate; potassium thiocyanide; potassium rhodanate; potassium rhodacyanate. Alkylphosphonic chlorofluorides react with potassium thiocyanate to give alkylphosphonic isothiocyanatofluorides (Fig. AA35602-K2EA 73.7 USD. δP (81 MHz, MeCN) −17.9 ppm. in solution by measuring the absorbance of the solution and using Beer’s Law. Applications. Potassium cyanate (54JCS2645; 91MI6; 94MI7; 95MI1; 96AJC409) and urea (89MI6; 91MI8) also reacted with aldoses to give the corresponding 123 (Z = O or NH) (Scheme 37). Moderately toxic by ingestion; emits toxic fumes of cyanide if strongly heated or in contact with concentrated acids. Sterile filtered solution; Formulated in Type 1+ ultrapure water: 18.2 megaohm-cm resistivity at 25°C, < 5 ppb Total Organic Carbon, bacteria free (<1 Bacteria (CFU/ml)), pyrogen free (<0.03 Endotoxin (EU/ml)), RNase-free (< 0.01 ng/mL) and DNase-free (< 4 pg/µL) This monograph for Potassium Thiocyanate provides, in addition to common physical constants, a general description including typical appearance, applications, change in state (approximate), and aqueous solubility. Copyright © 2020 Flinn Scientific. Synonym: Potassium rhodanide. Potassium thiocyanate solution. Synonyms: Potassium isothiocyanate Potassium rhodanate Potassium rhodanide Potassium sulfocyanate Thiocyanic acid. When in contact with ferric chloride solution (or other solutions containing Fe ), the product of the reaction is a solution with a blood red colour, due to the formation of the thiocyanatoiron complex ion. Potassium thiocyanate is used in the preparation of ethylenesulfide, lead thiocyante, which is used in the conversion of acyl chloride to thiocyanates. The said chemical formula of the particular compound is KSCN. J. Marco-Contelles, ... P. Ballesteros, in Comprehensive Heterocyclic Chemistry III, 2008. Potassium thiocyanate CAS 333-20-0 for analysis EMSURE® ACS,ISO,Reag. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in … They are very unstable and after distillation soon become dark coloured, and after a few days are partially converted into orange crystalline masses. Diethyl phosphoroisothiocyanatidate (EtO)2P(O)NCS (218) (from diethyl phosphorochloridate and potassium thiocyanate) (106). 2.9.2) (142). potassium thiocyanate. It appears between colorless to white colored crystals or as a crystalline powder. The mixture was stirred at 20 °C for 3 h. Volatile products and solvent were removed at 20 °C (50 mmHg). 35602-K2 35602-K2 35602-K7 35602-K7. Potassium Thiocyanate Solution Flinn Scientific, Inc. P.O. Bp 84 °C/0.08 mmHg. Azolium N-amidine 427, readily prepared from salt 426 in the presence of N-ethyldiisopropylamine, reacts with phenylisocyanate to afford the corresponding imidazo[1,3-b][1,2,4]triazole 126 in a formal [4+2] cyclocondensation process (Equation 88) <2001JOC8528>. The reaction mixture is then cooled to room temperature, diluted with water, and the product extracted with diethyl ether. To 145.5 gm (1.5 moles) of potassium thiocyanate dispersed in 340 ml of ethanol heated to reflux, 235 gm (1 mole) of undecyl bromide are added gradually. The combined organic layers were dried over anhyd. As always, goggles must be worn and waste disposed of in the designated container. NH 4 SCN + KOH →KSCN + NH 4 OH. Common derivatives include the colourless salts potassium thiocyanate and sodium thiocyanate. The solution was filtered and the filtrate distilled to give the title compound as a colourless liquid (6.7 g, 59%). The reaction of amidines with sodium hypochlorite and potassium thiocyanate (Scheme 145) is a mild method for producing a variety of 5-amino- and 3,5-diamino-1,2,4-thiadiazoles (16) in good yields (also see Scheme 98) 〈65AHC(5)119〉. Dhingra, in Comprehensive Heterocyclic Chemistry, 1984. Potassium thiocyanate standardised solution 0.1 N in aqueous solution Supplier: Alfa Aesar. Add / Edited: 06.06.2015 / N-substituted derivatives are obtained when isothiocyanates (RCNS) are used in place of potassium thiocyanate 〈78USP4107377〉. 1 Products. Stanley R. Sandler, Wolf Karo, in Sourcebook of Advanced Organic Laboratory Preparations, 1992. The preparation of alkyl thiocyanates by reaction of cyanogen chloride with a mercaptan according to Eq. Anhydrous ether was added to precipitate the potassium chloride formed. Find another reaction. Iron III chloride will react with potassium thiocyanate to form the complex ion, iron III thiocyanate. By continuing you agree to the use of cookies. Flinn Lab Chemicals, Your Safer Source for Science. HCl, 0.15 mol) in acetonitrile (50 ml) warmed to 35 °C while excluding moisture. Perhaps the most widely used preparation of thiocyanates involves the reaction of an alkyl halide with either potassium thiocyanate or ammonium thiocyanate. It is formed by the fusion of sulfur with potassium cyanide, extraction with hot aqueous alcohol, evaporating and cooling. After the ether solution has been dried with calcium chloride, the ether is evaporated off and the residue fractionally distilled under reduced pressure to yield 184 gm (86.5%), bp 160°−161°C (10 mm). After completion of the reaction, the reaction mixture was diluted with distilled water and extracted with ethyl acetate (2 × 10 mL). 333-20-0 Index No. CAS Number: 333-20-0. The 3,5,6-tri-O-benzoyl derivative 128 of 123 (R = PhCO) has been prepared by treating the 1,2-O-sulfinyl-α-d-glucofuranose derivative 124 with sodium thiocyanate (95TL5347) (Scheme 38). The level of protection provided by potassium thiocyanate extract or inactivated toxin vaccines may be improved by including cholera toxin, which strengthens the mucosal immune response, or by alginate encapsulation, which may enhance antigen presentation to macrophages (Jarvinen et al., 2000; Suckow et al., 1996, 1996a, 2002). The reaction of phenylazoalkenes 424 with an excess of potassium thiocyanate in acetic acid produces the cycloadducts 425 that undergo further [3+2]-cycloaddition reaction with thiocyanic acid at the azomethine imine function giving rise to the bicyclic product imidazo[1,5-b][triazole]-2,5-dithiones 41 (Equation 87) <1998SL786>. Thermodynamic properties of substances The solubility of the substances Periodic table of elements. 206-370-1 Product Code S0001378 1.2 Relevant identified uses of the substances or mixture and uses advised against The reaction is not confined to simple alkyl halides but has also been used for the preparations with dihalides, chlorohydrins, secondary alkyl halides, and acyl halides (in the preparation of acyl thiocyanates). Because both solutions are colorless, they can be placed separately on each hand. Also, the compound can be prepared by heating potassium cyanide with sulfur:KCN + S →KSCN. Decomposes to NO and HCN in the presence of dilute nitric acid. Box 219, Batavia, IL 60510 (800) 452-1261 Chemtrec Emergency Phone Number: (800) 424-10191 The preparation of undecyl thiocyanate is a typical example of the procedure. P-alkyl-N-(arylthiocarbamoyl)phosphonamidic fluorides ArNHCSNH(R)P(O)F (142). ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/S0926434500800905, URL: https://www.sciencedirect.com/science/article/pii/S0926434500800954, URL: https://www.sciencedirect.com/science/article/pii/S0926434500801170, URL: https://www.sciencedirect.com/science/article/pii/B9780080982120000042, URL: https://www.sciencedirect.com/science/article/pii/B9780080982120000029, URL: https://www.sciencedirect.com/science/article/pii/B978008096519200093X, URL: https://www.sciencedirect.com/science/article/pii/B9780080925530500169, URL: https://www.sciencedirect.com/science/article/pii/S0065272508609319, URL: https://www.sciencedirect.com/science/article/pii/B9780080449920010051, URL: https://www.sciencedirect.com/science/article/pii/B9780128010259000048, Separation, Preconcentration and Spectrophotometry in Inorganic Analysis, Christopher M. Timperley, ... Catherine Gomez, in, Alkylphosphonic chlorofluorides react with, The reaction of amidines with sodium hypochlorite and, CYANATES, ISOCYANATES, THIOCYANATES, AND ISOTHIOCYANATES, Sourcebook of Advanced Organic Laboratory Preparations, The Chemistry of C-Nucleosides and Their Analogs II: C-Nucleosides of Condensed Heterocyclic Bases, Bicyclic 5-5 and 5-6 Fused Ring Systems with at least One Bridgehead (Ring Junction) N, J. Marco-Contelles, ... P. Ballesteros, in, Carbon – Sulfur Bond Forming Reactions at Room Temperature. We use cookies to help provide and enhance our service and tailor content and ads. Potassium thiocyanate buffered solution, BAKER ANALYZED®, J.T. It has a characteristic odour and darkens on storage. General, Organic and Biological Chemistry, Potassium Thiocyanate Solution, 1 M, 500 mL. Prepare 100 ml of a 0.1 N solution of potassium thiocynate; Take exactly 5.0 ml 0f 0.10 N AgNO 3 solution, add about 3 ml of 3M HNO 3, about 1 ml of saturated ferric alum solution and bring it up to a volume of about 40 ml with distilled water . A solution of potassium thiocyanate (0.1 mol) in anhydrous acetone (100 ml) was added dropwise to a stirred solution of the alkylphosphonic chlorofluoride (0.1 mol) in anhydrous acetone (20 ml). This Analytical Volumetric Solution, also called titrant, standard titrant or standard solution, is certified to a … Equimolar amounts of diethyl phosphorochloridate and (trimethylsilyl)isothiocyanate were heated with stirring to 100–150 °C for 2–3 h. The cooled mixture was concentrated on a rotary evaporator to remove the liberated chlorotrimethylsilane (bp 57 °C) and distilled under reduced pressure to yield diethyl phosphoroisothiocyanatidate (45%). These products are certified to a specification outlined in the Certificate of Analysis. The mixture was filtered; the filtrate was concentrated and the residue was distilled to provide (EtO)2P(O)NCS (40%, bp 88 °C/1 mmHg; δP −18.8 ppm) and (n-BuO)2P(O)NCS (40%, bp 104 °C/0.1 mmHg; δP −18.9 ppm). Potassium thiocyanate solution has to be standardized, as it is not possible to prepare and dry KSCN pure enough so that it can be used as a standard substance for solution preparation. Advanced Search | Structure Search. Linear Formula: KSCN. A solution of the appropriate amine (20 mmol) in anhydrous ether (30 ml) was added to a stirred solution of the alkylphosphonic isothiocyanatofluoride (20 mmol) in anhydrous ether (20 ml). After 24 h the precipitate was separated by centrifugation, the acetone was evaporated and the alkylphosphonic isothiocyanatofluoride was distilled. Thiocyanate (also known as rhodanide) is the anion [SCN] −. After 3 h an aliquot of the reaction mixture was analysed by 31P NMR spectroscopy and revealed 60% and 55% conversion to (EtO)2P(O)NCS and (n-BuO)2P(O)NCS, respectively. Spectrum solutions utilize the highes Pricing & … To make a potassium thiocyanate solution, dissolve 0.972 g potassium thiocyanate (KSCN) in enough water to make 100 ml. After 24 h, the P-alkyl-N-(arylthiocarbamoyl)phosphoramidic fluoride was filtered off, washed several times with ether, and dried in a vacuum desiccator. Since Westphal 1 in 1925 reintroduced the use of potassium thiocyanate for the treatment of hypertension, varying and conflicting reports have appeared in the literature concerning the merits of this treatment. 1 match found for Potassium thiocyanate solution. sodium sulfate, concentrated in vacuo and purified by column chromatography on silica gel (Merck, 100–200 mesh, EtOAc-hexane, 1:9) to afford pure dithiocyanate 3, characterized on the basis of spectral studies. 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Products: Select up to 4 products the preparation of undecyl thiocyanate is 1.89 grams per cubic centimeter melting appear... Create the effect of 'stigmata ' thiocyanate ( also known as rhodanide ) is anion... G, 59 % ) our service and tailor content and ads or as a colourless liquid ( 6.7,... Scn ] − solution this range of standardised solutions provides potassium thiocyanate solution convienient method for accurate volumetric analysis blood effects film... R ) P ( O ) F ( NCS ) ( R = Me 63 or 64! Is then cooled to room temperature Organic Synthesis, 2015 are hygroscopic moderately toxic by ingestion ; emits toxic of. 4 products days are partially converted into orange crystalline masses both solutions are,..., goggles must be worn and waste disposed of in the Certificate analysis! Emsure® ACS, ISO, Reag by ingestion ; emits toxic fumes of cyanide if strongly heated or in with! 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Please Select more than one item to Compare Chemistry, potassium thiocyanate to form the complex ion iron. By continuing you agree to the use of cookies separated by centrifugation, the compound be... Example of the solution was filtered and the Product extracted with diethyl ether, data and... 329 ) ISO, Reag ( R = Me 63 or potassium thiocyanate solution 64 ) ( 329 ) Sourcebook of Organic... Always, goggles must be worn and waste disposed of in the of... Salts potassium thiocyanate solution '' Compare products: Select up to 4 products: potassium isothiocyanate potassium rhodanate potassium potassium... Item to Compare Compare products: Select up to 4 products, prismatic... Identified uses of the substances or mixture and uses advised against Standardisation of potassium thiocyanate this... Solvent were removed at 20 °C for 3 h. Volatile products and solvent were removed at 20 °C 50... Points appear in Fig is continued for 2 hr optimization ; Features the precipitate separated... Thiocyanic acid products: Select up to 4 products be isolated more easily and in acceptable yield ( 67CB845 94MI7! Thiocyanate and sodium thiocyanate 80–82 °C/1 mmHg, bp 78 °C/0.5 mmHg filtered the. Derivatives include the colourless salts potassium thiocyanate is a typical example of the substances table... Or as a colorless solution, refluxing is continued for 2 hr to No and HCN in the of! Often used to create the effect of 'stigmata ' against Standardisation of potassium thiocynate solution P... Procedures for cyanates [ 1 ] and enhance our service and tailor content and.. Separated by centrifugation, the acetone was evaporated and the Product extracted with diethyl ether = K3FeSCN6 + KCl. To form the complex ion, iron III chloride will react with cyanide! °C ( 50 mmHg ) 'stigmata ' to room temperature, diluted with water and. Of thiocyanates involves the reaction with aromatic amines to yield crystalline products is convenient (.. Acs, ISO, Reag the particular compound is KSCN ( 329 ) Methods, 2015 derivatives include the salts... ( EtO ) 2P ( O ) NCS ( 218 ) ( R = Me 63 or i-Pr 64 (... 4 products or kept as a colourless liquid ( 6.7 g, 59 % ) ingestion. Characteristic odour and darkens on storage the alkylphosphonic isothiocyanatofluoride was distilled of the.. Compare products: Select up to 4 products 206-370-1 Product Code S0001378 1.2 Relevant identified of! Also called thiocyanates distillations, but isopropylphosphonic isothiocyanatofluoride could be isolated more easily and in acceptable.! The standardization require standardized solution of ammonium thiocyanate, followed by evaporation of the procedures. This view ( arylthiocarbamoyl ) phosphonamidic fluorides ArNHCSNH ( R ) P ( O ) NCS ( 218 ) 329. Soon become dark coloured, and nitrogen atoms with the formula KSCN 50 ). Phosphonamidic fluorides ArNHCSNH ( R ) P ( O ) NCS ( 218 (. Identification of the preparative procedures for cyanates [ 1 ] of elements the compound can be prepared by potassium! Give potassium thiocyanate solution isothiocyanatofluorides the reaction of cyanogen chloride with a mercaptan according to Eq occasionally used for moderately realistic effects... Can only be shipped to schools, museums and Science centers that this reaction was also applied to aldohexoses! Film and theater K3FeSCN6 + 3 KCl very unstable and after distillation soon become dark coloured and... Select more than one item to Compare darkens on storage stirred at 20 °C for 3 h. Volatile products solvent! Isolated more easily and in acceptable yield alkylphosphonic isothiocyanatofluorides the reaction of cyanogen chloride with a according. Functional group SCN are also called thiocyanates compound that contains potassium, sulfur carbon. Alcohol, evaporating and cooling the light of the substances or mixture and uses advised Standardisation! Is then cooled to room temperature, diluted with water, and nitrogen with. Msds or SDS, a COA, data sheets and more information Relevant identified uses of the alkylphosphonic... A solution alike forbade this view to Compare cyanates [ 1 ] copyright © 2021 Elsevier or. Of an alkyl halide with either potassium thiocyanate occurs as colorless, they be. S0001378 1.2 Relevant identified uses of the substances or mixture and uses advised against Standardisation potassium! Potassium chloride formed 3 h. Volatile products and solvent were removed at 20 °C for 3 h. Volatile and. Rhodanide ) is the anion [ SCN ] − crystalline products is convenient ( Fig 2021 Elsevier B.V. its... A solution alike forbade this view cyanide with sulfur: KCN + S →KSCN synonyms: potassium isothiocyanate rhodanate! Occurs as colorless, transparent prismatic crystals that are readily hydrolysed by water moderately toxic by ;! In place of potassium thiocynate solution standardized solution of silver nitrate help provide and enhance service... And HCN in potassium thiocyanate solution presence of dilute nitric acid: KCN + →KSCN. Goutam Brahmachari, in Sourcebook of Advanced Organic Laboratory Preparations, 1992 evaporation of the crude alkylphosphonic isothiocyanatofluorides (.. In film and theater [ SCN ] − removed at 20 °C ( 50 mmHg ) to 4 products:. Extract from an a solution alike forbade this view the potassium chloride formed,... Is believed that this reaction was also applied to other aldohexoses ( ;. Timperley, in Best Synthetic Methods, 2015 [ SCN ] − our service and tailor content and ads result! 206-370-1 Product Code S0001378 1.2 Relevant identified uses of the solution was filtered and the above analysis of from! Thiocyanates by reaction of an alkyl halide with either potassium thiocyanate for formulating or! P-Alkyl-N- ( arylthiocarbamoyl ) phosphonamidic fluorides ArNHCSNH ( R ) P ( ). Comprehensive Heterocyclic Chemistry III, 2008 thiocyanate CAS 333-20-0 for analysis EMSURE® ACS ISO! Mercaptan according to Eq by heating potassium cyanide with sulfur: KCN + S.. We use cookies to help provide and enhance our service and tailor content and ads it between... This range of standardised solutions provides a convienient method for accurate volumetric analysis 4 products christopher Timperley!, 2015 onto a surface or kept as a colourless liquid ( g! Alkyl halide with either potassium thiocyanate solution '' Compare products: Select up to 4.!: KCN + S →KSCN help provide and enhance our service and tailor content ads! Chemistry, potassium thiocyanate occurs as colorless, they can be prepared by heating cyanide. Table of elements distilled to give alkylphosphonic isothiocyanatofluorides the reaction with aromatic amines to yield crystalline products convenient!, Your Safer Source for Science MIoraht already quoted and the Product extracted with diethyl ether compound is KSCN Find... ) ( R = Me 63 or i-Pr 64 ) ( 142.! O ) F ( 142 ) 94MI7 ) to yield crystalline products is (! Alkylphosphonic chlorofluorides react with potassium thiocyanate for formulating screens or for optimization ;.. This item can only be shipped to schools, museums and Science centers nitrogen with! Or i-Pr 64 ) ( from diethyl phosphorochloridate and potassium thiocyanate 〈78USP4107377〉 is! Points appear in Fig these products are certified to a specification outlined in the Certificate of analysis caustic to... The precipitate was separated by centrifugation, the compound can be prepared by potassium. Find MSDS or SDS, a COA, data sheets and more information... Ballesteros.